LETMD1 (Gene)

Entrez Gene ID: 25875

Description: LETM1 domain containing 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LETMD1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with LETMD1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using LETMD1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for LETMD1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with LETMD1.

Gene Sets (314)

LINCS L1000 Chem Pert Consensus Sigs (210)

A gene set library provided by LINCS

KOMP2 Mouse Phenotypes 2022 (7)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (93)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (4)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target	Evidence
9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LETMD1 Gene (Entity type)	0.013146974
staurosporine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LETMD1 Gene (Entity type)	0.008229016
pralatrexate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LETMD1 Gene (Entity type)	0.013592115
1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LETMD1 Gene (Entity type)	0.0055169347
AZD-2014::CHEMBL2336325::US9102670, 1ap Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LETMD1 Gene (Entity type)	0.010743288
5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LETMD1 Gene (Entity type)	0.016626116
Lestaurtinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LETMD1 Gene (Entity type)	0.009357949
dactolisib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LETMD1 Gene (Entity type)	0.011415294
BGT-226 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LETMD1 Gene (Entity type)	0.014360697
(S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LETMD1 Gene (Entity type)	0.010654224

9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LETMD1
Gene (Entity type)
0.013146974

staurosporine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LETMD1
Gene (Entity type)
0.008229016

pralatrexate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LETMD1
Gene (Entity type)
0.013592115

1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LETMD1
Gene (Entity type)
0.0055169347

AZD-2014::CHEMBL2336325::US9102670, 1ap
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LETMD1
Gene (Entity type)
0.010743288

5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LETMD1
Gene (Entity type)
0.016626116

Lestaurtinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LETMD1
Gene (Entity type)
0.009357949

dactolisib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LETMD1
Gene (Entity type)
0.011415294

BGT-226
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LETMD1
Gene (Entity type)
0.014360697

(S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LETMD1
Gene (Entity type)
0.010654224

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Knowledge Graph Assertions

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.