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pralatrexate (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View pralatrexate's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	pralatrexate Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Peripheral T-cell lymphoma, pleomorphic small cell Disease or Phenotype (Entity type)
	pralatrexate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CHRDL1 Gene (Entity type)	0.011836897
	pralatrexate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HAUS4 Gene (Entity type)	0.012583127
	pralatrexate Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Gemcitabine Compound (Entity type)	0.5891070365905762
	pralatrexate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLK1 Gene (Entity type)	-0.0330485
	pralatrexate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KIF14 Gene (Entity type)	-0.013234992
	pralatrexate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Reduced folate transporter Protein (Entity type)	IC50
	pralatrexate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PRAF2 Gene (Entity type)	0.012154666
	pralatrexate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Proton-coupled folate transporter Protein (Entity type)	IC50
	pralatrexate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KIF20A Gene (Entity type)	-0.026133556

pralatrexate
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Peripheral T-cell lymphoma, pleomorphic small cell
Disease or Phenotype (Entity type)

pralatrexate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CHRDL1
Gene (Entity type)
0.011836897

pralatrexate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HAUS4
Gene (Entity type)
0.012583127

pralatrexate
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Gemcitabine
Compound (Entity type)
0.5891070365905762

pralatrexate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLK1
Gene (Entity type)
-0.0330485

pralatrexate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
KIF14
Gene (Entity type)
-0.013234992

pralatrexate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Reduced folate transporter
Protein (Entity type)
IC50

pralatrexate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PRAF2
Gene (Entity type)
0.012154666

pralatrexate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Proton-coupled folate transporter
Protein (Entity type)
IC50

pralatrexate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
KIF20A
Gene (Entity type)
-0.026133556

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