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dactolisib (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View dactolisib's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	dactolisib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NAT1 Gene (Entity type)	-0.011692055
	1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	dactolisib Compound (Entity type)	0.8716692328453064
	dactolisib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MYC Gene (Entity type)	0.015802944
	PP-242 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	dactolisib Compound (Entity type)	0.3744906783103943
	dactolisib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RPL36 Gene (Entity type)	0.0101876035
	dactolisib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	EIF3L Gene (Entity type)	0.0096893385
	1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-methylurea Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	dactolisib Compound (Entity type)	0.8386304378509521
	(5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	dactolisib Compound (Entity type)	0.9168373346328736
	Temsirolimus Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	dactolisib Compound (Entity type)	0.785596489906311
	(S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	dactolisib Compound (Entity type)	0.831758975982666

dactolisib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NAT1
Gene (Entity type)
-0.011692055

1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
dactolisib
Compound (Entity type)
0.8716692328453064

dactolisib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MYC
Gene (Entity type)
0.015802944

PP-242
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
dactolisib
Compound (Entity type)
0.3744906783103943

dactolisib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RPL36
Gene (Entity type)
0.0101876035

dactolisib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
EIF3L
Gene (Entity type)
0.0096893385

1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-methylurea
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
dactolisib
Compound (Entity type)
0.8386304378509521

(5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
dactolisib
Compound (Entity type)
0.9168373346328736

Temsirolimus
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
dactolisib
Compound (Entity type)
0.785596489906311

(S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
dactolisib
Compound (Entity type)
0.831758975982666

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