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Serine/threonine-protein kinase SIK3 (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Serine/threonine-protein kinase SIK3 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase SIK3 Protein (Entity type)	Kd
	ARN-3236 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase SIK3 Protein (Entity type)	IC50
	Crenolanib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase SIK3 Protein (Entity type)	Kd
	SKI-606 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase SIK3 Protein (Entity type)	IC50
	HG-9-91-01 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase SIK3 Protein (Entity type)	IC50
	Sonolisib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase SIK3 Protein (Entity type)	Kd
	[3-{2-[(3,5-Dimethyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}-N-(2-{2-[2-(2-{[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]amino}ethoxy)ethoxy]ethoxy}ethyl)propanamidato](difluoro)borone Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase SIK3 Protein (Entity type)	Kd
	TG-100572 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase SIK3 Protein (Entity type)	Kd
	Staurosporine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase SIK3 Protein (Entity type)	Kd

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase SIK3
Protein (Entity type)
Kd

ARN-3236
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase SIK3
Protein (Entity type)
IC50

Crenolanib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase SIK3
Protein (Entity type)
Kd

SKI-606
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase SIK3
Protein (Entity type)
IC50

HG-9-91-01
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase SIK3
Protein (Entity type)
IC50

Sonolisib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase SIK3
Protein (Entity type)
Kd

[3-{2-[(3,5-Dimethyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}-N-(2-{2-[2-(2-{[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]amino}ethoxy)ethoxy]ethoxy}ethyl)propanamidato](difluoro)borone
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase SIK3
Protein (Entity type)
Kd

TG-100572
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase SIK3
Protein (Entity type)
Kd

Staurosporine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase SIK3
Protein (Entity type)
Kd

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025