N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide's neighborhood in the knowledge graph.

Submit

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Phenazopyridine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	0.2909723222255707
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GLIPR1 Gene (Entity type)	-0.0075806216
Manidipine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	0.2896713316440582
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase SIK3 Protein (Entity type)	Kd
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CAV2 Gene (Entity type)	-0.0077417763
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Ephrin type-A receptor 8 Protein (Entity type)	Kd
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TPM1 Gene (Entity type)	-0.010041115
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein-tyrosine kinase 6 Protein (Entity type)	Ki
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Ephrin type-A receptor 4 Protein (Entity type)	Kd
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	EMP1 Gene (Entity type)	-0.007769599

Phenazopyridine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
0.2909723222255707

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GLIPR1
Gene (Entity type)
-0.0075806216

Manidipine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
0.2896713316440582

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase SIK3
Protein (Entity type)
Kd

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CAV2
Gene (Entity type)
-0.0077417763

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Ephrin type-A receptor 8
Protein (Entity type)
Kd

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TPM1
Gene (Entity type)
-0.010041115

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein-tyrosine kinase 6
Protein (Entity type)
Ki

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Ephrin type-A receptor 4
Protein (Entity type)
Kd

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
EMP1
Gene (Entity type)
-0.007769599

DISPLAY PER PAGE

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
Loading results...

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.