4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MVP Gene (Entity type)	0.006054019
4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CDC45 Gene (Entity type)	-0.006488837
4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DHCR7 Gene (Entity type)	-0.005202086
4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	EIF5A Gene (Entity type)	-0.006699087
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	0.4394584000110626
4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CA12 Gene (Entity type)	0.006220807
4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	wortmannin Compound (Entity type)	0.4818400740623474
Danusertib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	0.4712393581867218
4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITGA3 Gene (Entity type)	0.0057308776
4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SPARCL1 Gene (Entity type)	-0.005473463

4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MVP
Gene (Entity type)
0.006054019

4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CDC45
Gene (Entity type)
-0.006488837

4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DHCR7
Gene (Entity type)
-0.005202086

4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
EIF5A
Gene (Entity type)
-0.006699087

N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
Compound (Entity type)
0.4394584000110626

4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CA12
Gene (Entity type)
0.006220807

4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
wortmannin
Compound (Entity type)
0.4818400740623474

Danusertib
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
Compound (Entity type)
0.4712393581867218

4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ITGA3
Gene (Entity type)
0.0057308776

4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SPARCL1
Gene (Entity type)
-0.005473463

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