N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HS3ST1 Gene (Entity type)	-0.00624673
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CDC25A Gene (Entity type)	-0.0050448026
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Aurora kinase A Protein (Entity type)	IC50
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SPP1 Gene (Entity type)	0.010957249
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Palbociclib; Ibrance Compound (Entity type)	0.3945709764957428
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SFRP4 Gene (Entity type)	-0.005394409
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Compound (Entity type)	0.4394584000110626
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RPS4Y1 Gene (Entity type)	0.005950726
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	POLE2 Gene (Entity type)	-0.0056487327
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KIF14 Gene (Entity type)	-0.007036407