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HKI-272 (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HKI-272's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	HKI-272 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Ponatinib Compound (Entity type)	0.660050630569458
	(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	HKI-272 Compound (Entity type)	0.6847005486488342
	HKI-272 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PSAT1 Gene (Entity type)	0.0131359305
	HKI-272 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	Kd
	HKI-272 Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	HER2-positive carcinoma of breast Disease or Phenotype (Entity type)
	JAK3 inhibitor II Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	HKI-272 Compound (Entity type)	0.4741996526718139
	HKI-272 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TSC22D3 Gene (Entity type)	0.019822305
	HKI-272 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-4 Protein (Entity type)	Kd
	dacomitinib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	HKI-272 Compound (Entity type)	0.511049747467041
	HKI-272 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RGS2 Gene (Entity type)	-0.0060691754

HKI-272
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Ponatinib
Compound (Entity type)
0.660050630569458

(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
HKI-272
Compound (Entity type)
0.6847005486488342

HKI-272
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PSAT1
Gene (Entity type)
0.0131359305

HKI-272
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
Kd

HKI-272
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
HER2-positive carcinoma of breast
Disease or Phenotype (Entity type)

JAK3 inhibitor II
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
HKI-272
Compound (Entity type)
0.4741996526718139

HKI-272
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TSC22D3
Gene (Entity type)
0.019822305

HKI-272
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-4
Protein (Entity type)
Kd

dacomitinib
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
HKI-272
Compound (Entity type)
0.511049747467041

HKI-272
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RGS2
Gene (Entity type)
-0.0060691754

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