(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLAT Gene (Entity type)	-0.009362468
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	HKI-272 Compound (Entity type)	0.6847005486488342
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCK2 Gene (Entity type)	0.010750757
CGP-52411 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	0.273940235376358
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	0.013427399
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NIBAN1 Gene (Entity type)	0.0072339093
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SPINK1 Gene (Entity type)	0.0071658934
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CHAC1 Gene (Entity type)	0.014357508
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	C7 Gene (Entity type)	-0.0076803374
Erlotinib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	0.6079968214035034

(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLAT
Gene (Entity type)
-0.009362468

(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
HKI-272
Compound (Entity type)
0.6847005486488342

(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCK2
Gene (Entity type)
0.010750757

CGP-52411
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
0.273940235376358

(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PHGDH
Gene (Entity type)
0.013427399

(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NIBAN1
Gene (Entity type)
0.0072339093

(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SPINK1
Gene (Entity type)
0.0071658934

(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CHAC1
Gene (Entity type)
0.014357508

(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
C7
Gene (Entity type)
-0.0076803374

Erlotinib
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
0.6079968214035034

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Knowledge Graph Assertions

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