HKI-272 (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HKI-272's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
HKI-272 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Ponatinib Compound (Entity type)	0.660050630569458
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	HKI-272 Compound (Entity type)	0.6847005486488342
HKI-272 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PSAT1 Gene (Entity type)	0.0131359305
HKI-272 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	Kd
HKI-272 Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	HER2-positive carcinoma of breast Disease or Phenotype (Entity type)
JAK3 inhibitor II Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	HKI-272 Compound (Entity type)	0.4741996526718139
HKI-272 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TSC22D3 Gene (Entity type)	0.019822305
HKI-272 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-4 Protein (Entity type)	Kd
dacomitinib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	HKI-272 Compound (Entity type)	0.511049747467041
HKI-272 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RGS2 Gene (Entity type)	-0.0060691754

HKI-272
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Ponatinib
Compound (Entity type)
0.660050630569458

(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
HKI-272
Compound (Entity type)
0.6847005486488342

HKI-272
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PSAT1
Gene (Entity type)
0.0131359305

HKI-272
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
Kd

HKI-272
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
HER2-positive carcinoma of breast
Disease or Phenotype (Entity type)

JAK3 inhibitor II
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
HKI-272
Compound (Entity type)
0.4741996526718139

HKI-272
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TSC22D3
Gene (Entity type)
0.019822305

HKI-272
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-4
Protein (Entity type)
Kd

dacomitinib
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
HKI-272
Compound (Entity type)
0.511049747467041

HKI-272
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RGS2
Gene (Entity type)
-0.0060691754

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Knowledge Graph Assertions

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