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Receptor tyrosine-protein kinase erbB-3 (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Receptor tyrosine-protein kinase erbB-3 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	HKI-272 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	Kd
	9-Cyclopentyl-N-(4-(4-methylpiperazin-1-yl)phenyl)-8-(phenylsulfinyl)-9H-purin-2-amine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	IC50
	5-((6-Morpholinopyrimidin-4-yl)amino)-5-oxopentanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	IC50
	9-Cyclopentyl-N-(4-(4-methylpiperazin-1-yl)phenyl)-8-(phenylthio)-9H-purin-2-amine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	IC50
	TX1-85-1 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	IC50
	N-((3R,4R)-4-Fluoro-1-(9-isopropyl-6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	IC50
	1-((3R,4R)-3-((5-chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	IC50
	N-((3R,4R)-4-Fluoro-1-(9-isopropyl-6-((3-methyl-1-methyl-1H-pyrazol-4-yl)amino)-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	IC50
	SKI-606 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	Kd
	N-(4-(2-(Dimethylamino)ethoxy)phenyl)-8-((3-fluorophenyl)thio)-9-(tetrah-ydro-2H-pyran-4-yl)-9H-purin-2-amine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-3 Protein (Entity type)	IC50

HKI-272
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
Kd

9-Cyclopentyl-N-(4-(4-methylpiperazin-1-yl)phenyl)-8-(phenylsulfinyl)-9H-purin-2-amine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
IC50

5-((6-Morpholinopyrimidin-4-yl)amino)-5-oxopentanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
IC50

9-Cyclopentyl-N-(4-(4-methylpiperazin-1-yl)phenyl)-8-(phenylthio)-9H-purin-2-amine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
IC50

TX1-85-1
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
IC50

N-((3R,4R)-4-Fluoro-1-(9-isopropyl-6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
IC50

1-((3R,4R)-3-((5-chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
IC50

N-((3R,4R)-4-Fluoro-1-(9-isopropyl-6-((3-methyl-1-methyl-1H-pyrazol-4-yl)amino)-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
IC50

SKI-606
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
Kd

N-(4-(2-(Dimethylamino)ethoxy)phenyl)-8-((3-fluorophenyl)thio)-9-(tetrah-ydro-2H-pyran-4-yl)-9H-purin-2-amine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-3
Protein (Entity type)
IC50

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