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VX-680/MK-0457 (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View VX-680/MK-0457's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	VX-680/MK-0457 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CENPE Gene (Entity type)	0.0048999214
	VX-680/MK-0457 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	INSIG1 Gene (Entity type)	0.005437281
	VX-680/MK-0457 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	EIF5A Gene (Entity type)	-0.005501057
	VX-680/MK-0457 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Uncharacterized protein FLJ45252 Protein (Entity type)	Kd
	VX-680/MK-0457 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	-0.0031162119
	VX-680/MK-0457 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SCD Gene (Entity type)	0.005387859
	VX-680/MK-0457 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RPS27L Gene (Entity type)	0.0045307376
	VX-680/MK-0457 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	QPRT Gene (Entity type)	0.0051443726
	VX-680/MK-0457 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SQLE Gene (Entity type)	0.005441213
	VX-680/MK-0457 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RGS4 Gene (Entity type)	-0.0032448797

VX-680/MK-0457
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CENPE
Gene (Entity type)
0.0048999214

VX-680/MK-0457
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
INSIG1
Gene (Entity type)
0.005437281

VX-680/MK-0457
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
EIF5A
Gene (Entity type)
-0.005501057

VX-680/MK-0457
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Uncharacterized protein FLJ45252
Protein (Entity type)
Kd

VX-680/MK-0457
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SIK1
Gene (Entity type)
-0.0031162119

VX-680/MK-0457
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SCD
Gene (Entity type)
0.005387859

VX-680/MK-0457
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RPS27L
Gene (Entity type)
0.0045307376

VX-680/MK-0457
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
QPRT
Gene (Entity type)
0.0051443726

VX-680/MK-0457
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SQLE
Gene (Entity type)
0.005441213

VX-680/MK-0457
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RGS4
Gene (Entity type)
-0.0032448797

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