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BGT-226 (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View BGT-226's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Tools & Use Cases

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	BGT-226 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	AMIGO2 Gene (Entity type)	0.011090265
	BGT-226 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	EIF3D Gene (Entity type)	0.011474068
	BGT-226 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(5-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol Compound (Entity type)	0.7239861488342285
	BGT-226 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Protein (Entity type)	IC50
	BGT-226 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-methylurea Compound (Entity type)	0.7316129207611084
	BGT-226 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	EBP Gene (Entity type)	-0.012301753
	BGT-226 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase mTOR Protein (Entity type)	IC50
	BGT-226 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LMNB1 Gene (Entity type)	-0.012416266
	BGT-226 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ABCC3 Gene (Entity type)	0.012494846
	BGT-226 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PPP1R3C Gene (Entity type)	-0.013489058

BGT-226
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
AMIGO2
Gene (Entity type)
0.011090265

BGT-226
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
EIF3D
Gene (Entity type)
0.011474068

BGT-226
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(5-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
Compound (Entity type)
0.7239861488342285

BGT-226
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Protein (Entity type)
IC50

BGT-226
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-methylurea
Compound (Entity type)
0.7316129207611084

BGT-226
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
EBP
Gene (Entity type)
-0.012301753

BGT-226
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase mTOR
Protein (Entity type)
IC50

BGT-226
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LMNB1
Gene (Entity type)
-0.012416266

BGT-226
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ABCC3
Gene (Entity type)
0.012494846

BGT-226
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PPP1R3C
Gene (Entity type)
-0.013489058

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