PDE4D (Gene)

Description: phosphodiesterase 4D

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PDE4D's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PDE4D.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PDE4D.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PDE4D.

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Gene Sets (746)

LINCS L1000 Chem Pert Consensus Sigs (367)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (2)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (359)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (3)

A gene set library provided by GTEx

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (3)

A gene set library provided by MoTrPAC

IDG Drug Targets 2022 (12)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
IDRA-21 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PDE4D Gene (Entity type)	0.03608552
kidney connecting tubule epithelial cell Anatomy (Entity type)	Has marker gene in kidney Knowledge Graph Relation (Entity type)	PDE4D Gene (Entity type)
PGE<sub>2</sub> Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PDE4D Gene (Entity type)	0.01975337
Importazole Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PDE4D Gene (Entity type)	-0.00686511
kidney cortex collecting duct principal cell Anatomy (Entity type)	Has marker gene in kidney Knowledge Graph Relation (Entity type)	PDE4D Gene (Entity type)
amitriptyline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PDE4D Gene (Entity type)	-0.0048484695
KFGENEBIN:PDE4D-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	PDE4D Gene (Entity type)
kidney connecting tubule principal cell Anatomy (Entity type)	Has marker gene in kidney Knowledge Graph Relation (Entity type)	PDE4D Gene (Entity type)
Iloprost Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PDE4D Gene (Entity type)	0.0052750343
SID11114047 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PDE4D Gene (Entity type)	0.008362131