2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid's neighborhood in the knowledge graph.

Submit

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Nutlin-2 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Compound (Entity type)	0.661383330821991
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IFIT1 Gene (Entity type)	-0.0053931153
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	EPHA2 Gene (Entity type)	0.004736674
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RGS2 Gene (Entity type)	0.004867167
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	0.005505155
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGA2 Gene (Entity type)	0.005434523
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	STMN1 Gene (Entity type)	-0.005463599
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FOXM1 Gene (Entity type)	-0.005456558
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TOP2A Gene (Entity type)	-0.006673343
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CDC20 Gene (Entity type)	-0.006166892

Nutlin-2
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
Compound (Entity type)
0.661383330821991

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IFIT1
Gene (Entity type)
-0.0053931153

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
EPHA2
Gene (Entity type)
0.004736674

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RGS2
Gene (Entity type)
0.004867167

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
0.005505155

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGA2
Gene (Entity type)
0.005434523

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
STMN1
Gene (Entity type)
-0.005463599

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FOXM1
Gene (Entity type)
-0.005456558

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TOP2A
Gene (Entity type)
-0.006673343

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CDC20
Gene (Entity type)
-0.006166892

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