4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CCL20 Gene (Entity type)	0.009100665
SU11652 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	0.2800159156322479
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ID2 Gene (Entity type)	-0.013146281
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GPI Gene (Entity type)	-0.0052183038
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Bone morphogenetic protein receptor type-1B Protein (Entity type)	IC50
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Bone morphogenetic protein receptor type-1A Protein (Entity type)	IC50
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	avicin-g Compound (Entity type)	0.426839143037796
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	0.0062932614
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MYB Gene (Entity type)	0.0060220887
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AKR1C3 Gene (Entity type)	-0.010072656

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CCL20
Gene (Entity type)
0.009100665

SU11652
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
0.2800159156322479

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ID2
Gene (Entity type)
-0.013146281

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GPI
Gene (Entity type)
-0.0052183038

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Bone morphogenetic protein receptor type-1B
Protein (Entity type)
IC50

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Bone morphogenetic protein receptor type-1A
Protein (Entity type)
IC50

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
avicin-g
Compound (Entity type)
0.426839143037796

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
0.0062932614

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MYB
Gene (Entity type)
0.0060220887

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AKR1C3
Gene (Entity type)
-0.010072656

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Knowledge Graph Assertions

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