DUSP4 (Gene)

Ensembl Gene ID: ENSG00000120875

Entrez Gene ID: 1846

Description: dual specificity phosphatase 4

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View DUSP4's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with DUSP4.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using DUSP4.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for DUSP4.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with DUSP4.

Gene Sets (2876)

LINCS L1000 Chem Pert Consensus Sigs (555)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (3)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (294)

A gene set library provided by LINCS

rummageo gene perturbations (309)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (10)

A gene set library provided by GTEx

RummaGEO DrugPerturbations 2025 (695)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (467)

A gene set library provided by LINCS

rummageo chemical perturbations (534)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (3)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (4)

A gene set library provided by GTEx

HuBMAP ASCT-B (1)

A gene set library provided by HuBMAP

Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-hydroxy-7-oxo-7-(2-(4-(pyridin-2-yl)benzylidene)hydrazinyl)heptanamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	-0.019465227
Ro-4987655 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	-0.01719431
Erlotinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	-0.0040431498
4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	0.007357301
8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	-0.0138921505
forskolin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	0.0058087227
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	0.0062932614
QL-XI-92 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	0.00442656
SID11113946 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	-0.006393829
WZ-7043 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DUSP4 Gene (Entity type)	-0.0062165363

N-hydroxy-7-oxo-7-(2-(4-(pyridin-2-yl)benzylidene)hydrazinyl)heptanamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
-0.019465227

Ro-4987655
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
-0.01719431

Erlotinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
-0.0040431498

4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
0.007357301

8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
-0.0138921505

forskolin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
0.0058087227

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
0.0062932614

QL-XI-92
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
0.00442656

SID11113946
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
-0.006393829

WZ-7043
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DUSP4
Gene (Entity type)
-0.0062165363

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Knowledge Graph Assertions

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CFDE Workbench

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.