(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide's neighborhood in the knowledge graph.

Submit

Knowledge Graph Assertions

Source	Relation	Target	Evidence
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TES Gene (Entity type)	-0.010648215
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CRIP1 Gene (Entity type)	0.014149897
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ARNT2 Gene (Entity type)	-0.010534814
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FKBP11 Gene (Entity type)	-0.011280677
filgotinib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide Compound (Entity type)	0.3609053194522857
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DNAJA3 Gene (Entity type)	0.01969079
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SNRPB Gene (Entity type)	0.010278433
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAGEA12 Gene (Entity type)	-0.01178955
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAGEA6 Gene (Entity type)	-0.01590673
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HOPX Gene (Entity type)	0.010514869

(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TES
Gene (Entity type)
-0.010648215

(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CRIP1
Gene (Entity type)
0.014149897

(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ARNT2
Gene (Entity type)
-0.010534814

(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FKBP11
Gene (Entity type)
-0.011280677

filgotinib
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Compound (Entity type)
0.3609053194522857

(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DNAJA3
Gene (Entity type)
0.01969079

(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SNRPB
Gene (Entity type)
0.010278433

(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MAGEA12
Gene (Entity type)
-0.01178955

(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MAGEA6
Gene (Entity type)
-0.01590673

(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HOPX
Gene (Entity type)
0.010514869

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Knowledge Graph Assertions

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