MCL1 (Gene)

Entrez Gene ID: 4170

Description: MCL1 apoptosis regulator, BCL2 family member

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View MCL1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with MCL1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using MCL1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for MCL1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with MCL1.

Gene Sets (3428)

LINCS L1000 Chem Pert Consensus Sigs (636)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (15)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (12)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (862)

A gene set library provided by LINCS

rummageo gene perturbations (248)

A gene set library provided by LINCS

RummaGEO DrugPerturbations 2025 (529)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (714)

A gene set library provided by LINCS

rummageo chemical perturbations (407)

A gene set library provided by LINCS

GTEx Tissues V8 2023 (3)

A gene set library provided by GTEx

IDG Drug Targets 2022 (2)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
MW-A1-12 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MCL1 Gene (Entity type)	0.005430783
Clobetasol propionate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MCL1 Gene (Entity type)	0.009044832
Lenvatinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MCL1 Gene (Entity type)	-0.004490704
SA-85901 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MCL1 Gene (Entity type)	-0.009501051
Rimexolone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MCL1 Gene (Entity type)	0.007703617
Iloprost Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MCL1 Gene (Entity type)	0.005341008
Olcegepant Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MCL1 Gene (Entity type)	-0.005887619
Istaroxime Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MCL1 Gene (Entity type)	0.004350782
[3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-propyl]-methyl-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MCL1 Gene (Entity type)	-0.0035388903
Bisacodyl Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MCL1 Gene (Entity type)	0.0066333786

MW-A1-12
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MCL1
Gene (Entity type)
0.005430783

Clobetasol propionate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MCL1
Gene (Entity type)
0.009044832

Lenvatinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MCL1
Gene (Entity type)
-0.004490704

SA-85901
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MCL1
Gene (Entity type)
-0.009501051

Rimexolone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MCL1
Gene (Entity type)
0.007703617

Iloprost
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MCL1
Gene (Entity type)
0.005341008

Olcegepant
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MCL1
Gene (Entity type)
-0.005887619

Istaroxime
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MCL1
Gene (Entity type)
0.004350782

[3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-propyl]-methyl-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MCL1
Gene (Entity type)
-0.0035388903

Bisacodyl
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MCL1
Gene (Entity type)
0.0066333786

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.