3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Non-Small Cell Lung Carcinoma Disease or Phenotype (Entity type)
3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	G0S2 Gene (Entity type)	-0.0036291094
3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NCAM1 Gene (Entity type)	-0.004192877
3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MMP1 Gene (Entity type)	-0.0034016513
3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FOLR1 Gene (Entity type)	-0.003013457
3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NSDHL Gene (Entity type)	0.0051146783
3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NQO1 Gene (Entity type)	-0.0031331284
3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Cyclizine Compound (Entity type)	0.4295190870761871
3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PDZK1IP1 Gene (Entity type)	-0.003655086
3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IDO1 Gene (Entity type)	-0.003258619

3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Non-Small Cell Lung Carcinoma
Disease or Phenotype (Entity type)

3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
G0S2
Gene (Entity type)
-0.0036291094

3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NCAM1
Gene (Entity type)
-0.004192877

3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MMP1
Gene (Entity type)
-0.0034016513

3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FOLR1
Gene (Entity type)
-0.003013457

3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NSDHL
Gene (Entity type)
0.0051146783

3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NQO1
Gene (Entity type)
-0.0031331284

3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Cyclizine
Compound (Entity type)
0.4295190870761871

3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PDZK1IP1
Gene (Entity type)
-0.003655086

3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IDO1
Gene (Entity type)
-0.003258619

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