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Crizotinib (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Crizotinib's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	Crizotinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGCR Gene (Entity type)	0.004565198
	Crizotinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Mer Protein (Entity type)	Kd
	Crizotinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CADM1 Gene (Entity type)	-0.0033508532
	Crizotinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Macrophage-stimulating protein receptor Protein (Entity type)	Kd
	Crizotinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ID3 Gene (Entity type)	-0.0033793258
	Crizotinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NT5E Gene (Entity type)	0.0036802415
	Crizotinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FADS2 Gene (Entity type)	0.0045492365
	Crizotinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Hepatocyte growth factor receptor Protein (Entity type)	IC50
	Crizotinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	INSIG1 Gene (Entity type)	0.008443191
	Crizotinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FASN Gene (Entity type)	0.0052709584

Crizotinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGCR
Gene (Entity type)
0.004565198

Crizotinib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Mer
Protein (Entity type)
Kd

Crizotinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CADM1
Gene (Entity type)
-0.0033508532

Crizotinib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Macrophage-stimulating protein receptor
Protein (Entity type)
Kd

Crizotinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ID3
Gene (Entity type)
-0.0033793258

Crizotinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NT5E
Gene (Entity type)
0.0036802415

Crizotinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FADS2
Gene (Entity type)
0.0045492365

Crizotinib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Hepatocyte growth factor receptor
Protein (Entity type)
IC50

Crizotinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
INSIG1
Gene (Entity type)
0.008443191

Crizotinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FASN
Gene (Entity type)
0.0052709584

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