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CFDE Workbench

HMGCR (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:3-hydroxy-3-methylglutaryl-CoA reductase, ENTREZ:3156, HGNC:5006, HMGCR, LDLCQ3, MIM:142910, NM_000859, NM_001130996, NM_001364187, NP_000850, NP_001124468, NP_001351116, XM_011543357, XM_011543358, XM_011543359, XP_011541659, XP_011541660, XP_011541661
Omim:OMIM:142910
Id:ENSG00000113161
Hgnc:HGNC:5006
Entrez:3156
Ensembl:ENSG00000113161
Description:3-hydroxy-3-methylglutaryl-CoA reductase
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HMGCR's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with HMGCR.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using HMGCR.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for HMGCR.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with HMGCR.

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    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
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