2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine)'s neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GJA1 Gene (Entity type)	-0.006676468
2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HLA-DQA1 Gene (Entity type)	-0.0055798762
2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RGS2 Gene (Entity type)	-0.006023327
2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	F13A1 Gene (Entity type)	0.003869756
2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	BGN Gene (Entity type)	0.0040060584
2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	5-hydroxytryptamine receptor 7 Protein (Entity type)	Ki
2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Potassium voltage-gated channel subfamily H member 2 Protein (Entity type)	IC50
2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Muscarinic acetylcholine receptor M3 Protein (Entity type)	Ki
2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	Ki
2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (Olanzapine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GABRP Gene (Entity type)	-0.0057528922