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Alpha-1A adrenergic receptor (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Alpha-1A adrenergic receptor 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine-3-carboxylic acid {3-[4-(4-fluoro-phenyl)-piperidin-1-yl]-propyl}-amide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	Ki
	5-Methyl-3-{1-[4-(1,1,3-trioxo-1,3-dihydro-1lambda6-benzo[d]isothiazol-2-yl)-butyl]-piperidin-4-yl}-3H-benzooxazol-2-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	Ki
	2-(4-Nitro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid {2-hydroxy-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propyl}-amide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	Ki
	2-[2-(1H-Pyrrol-2-yl)-phenoxymethyl]-4,5-dihydro-1H-imidazole Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	EC50
	rac-methyl 5-(3-(4,4-diphenylpiperidin-1-yl)propylcarbamoyl)-2,6-dimethyl-4-(naphthalen-2-yl)-1,4-dihydropyridine-3-carboxylate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	Ki
	3-{3-[4,4-Bis-(4-fluoro-phenyl)-piperidin-1-yl]-propylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	Ki
	(4aS,8aR)-benzyl 4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxaline-1(2H)-carboxylate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	Ki
	(R)-N-(3-(4-cyano-4-(4-cyanophenyl)piperidin-1-yl)propyl)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	Ki
	(S)-3-[(1R,3R)-3-(4-Cyano-4-phenyl-piperidin-1-yl)-cyclopentylcarbamoyl]-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	Ki
	N-[3-(4-Cyano-4-o-tolyl-piperidin-1-yl)-propyl]-2,2-di-p-tolyl-acetamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1A adrenergic receptor Protein (Entity type)	Ki

4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine-3-carboxylic acid {3-[4-(4-fluoro-phenyl)-piperidin-1-yl]-propyl}-amide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-1A adrenergic receptor
Protein (Entity type)
Ki

5-Methyl-3-{1-[4-(1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-yl)-butyl]-piperidin-4-yl}-3H-benzooxazol-2-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-1A adrenergic receptor
Protein (Entity type)
Ki

2-(4-Nitro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid {2-hydroxy-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propyl}-amide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-1A adrenergic receptor
Protein (Entity type)
Ki

2-[2-(1H-Pyrrol-2-yl)-phenoxymethyl]-4,5-dihydro-1H-imidazole
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-1A adrenergic receptor
Protein (Entity type)
EC50

rac-methyl 5-(3-(4,4-diphenylpiperidin-1-yl)propylcarbamoyl)-2,6-dimethyl-4-(naphthalen-2-yl)-1,4-dihydropyridine-3-carboxylate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-1A adrenergic receptor
Protein (Entity type)
Ki

3-{3-[4,4-Bis-(4-fluoro-phenyl)-piperidin-1-yl]-propylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-1A adrenergic receptor
Protein (Entity type)
Ki

(4aS,8aR)-benzyl 4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxaline-1(2H)-carboxylate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-1A adrenergic receptor
Protein (Entity type)
Ki

(R)-N-(3-(4-cyano-4-(4-cyanophenyl)piperidin-1-yl)propyl)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-1A adrenergic receptor
Protein (Entity type)
Ki

(S)-3-[(1R,3R)-3-(4-Cyano-4-phenyl-piperidin-1-yl)-cyclopentylcarbamoyl]-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-1A adrenergic receptor
Protein (Entity type)
Ki

N-[3-(4-Cyano-4-o-tolyl-piperidin-1-yl)-propyl]-2,2-di-p-tolyl-acetamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-1A adrenergic receptor
Protein (Entity type)
Ki

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