4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine's neighborhood in the knowledge graph.

Submit

Knowledge Graph Assertions

Source	Relation	Target	Evidence
4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	E2F2 Gene (Entity type)	-0.026860597
Crenolanib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine Compound (Entity type)	0.2729881107807159
4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	TGF-beta RI kinase inhibitor Compound (Entity type)	0.3579794764518738
4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SLC38A1 Gene (Entity type)	0.021418536
4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	VEGFA Gene (Entity type)	-0.026467912
4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CFD Gene (Entity type)	0.018261263
4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IGFBP5 Gene (Entity type)	-0.021034181
4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CASP2 Gene (Entity type)	0.017801335
4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TFF3 Gene (Entity type)	-0.029389398
4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HSPA8 Gene (Entity type)	0.018634167

4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
E2F2
Gene (Entity type)
-0.026860597

Crenolanib
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine
Compound (Entity type)
0.2729881107807159

4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
TGF-beta RI kinase inhibitor
Compound (Entity type)
0.3579794764518738

4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SLC38A1
Gene (Entity type)
0.021418536

4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
VEGFA
Gene (Entity type)
-0.026467912

4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CFD
Gene (Entity type)
0.018261263

4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IGFBP5
Gene (Entity type)
-0.021034181

4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CASP2
Gene (Entity type)
0.017801335

4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TFF3
Gene (Entity type)
-0.029389398

4-(2-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)ethyl)morpholine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HSPA8
Gene (Entity type)
0.018634167

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