cobimetinib (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View cobimetinib's neighborhood in the knowledge graph.

Source	Relation	Target	Evidence
cobimetinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HSPB8 Gene (Entity type)	0.008440276
cobimetinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Dual specificity mitogen-activated protein kinase kinase 7 Protein (Entity type)	IC50
cobimetinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase B-raf Protein (Entity type)	IC50
cobimetinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DTL Gene (Entity type)	-0.0075117755
cobimetinib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	TAK-733 Compound (Entity type)	0.80135178565979
cobimetinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CLU Gene (Entity type)	0.008053025
cobimetinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ARHGEF3 Gene (Entity type)	0.00652795
cobimetinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LIF Gene (Entity type)	-0.00812996
cobimetinib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	AZD-8330 Compound (Entity type)	0.7162032723426819
cobimetinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PHLDA1 Gene (Entity type)	-0.013013301

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	Source	Relation	Target	Evidence
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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

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