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cobimetinib (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View cobimetinib's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	cobimetinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HSPB8 Gene (Entity type)	0.008440276
	cobimetinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Dual specificity mitogen-activated protein kinase kinase 7 Protein (Entity type)	IC50
	cobimetinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase B-raf Protein (Entity type)	IC50
	cobimetinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DTL Gene (Entity type)	-0.0075117755
	cobimetinib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	TAK-733 Compound (Entity type)	0.80135178565979
	cobimetinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CLU Gene (Entity type)	0.008053025
	cobimetinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ARHGEF3 Gene (Entity type)	0.00652795
	cobimetinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LIF Gene (Entity type)	-0.00812996
	cobimetinib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	AZD-8330 Compound (Entity type)	0.7162032723426819
	cobimetinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PHLDA1 Gene (Entity type)	-0.013013301

cobimetinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HSPB8
Gene (Entity type)
0.008440276

cobimetinib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Dual specificity mitogen-activated protein kinase kinase 7
Protein (Entity type)
IC50

cobimetinib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase B-raf
Protein (Entity type)
IC50

cobimetinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DTL
Gene (Entity type)
-0.0075117755

cobimetinib
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
TAK-733
Compound (Entity type)
0.80135178565979

cobimetinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CLU
Gene (Entity type)
0.008053025

cobimetinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ARHGEF3
Gene (Entity type)
0.00652795

cobimetinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LIF
Gene (Entity type)
-0.00812996

cobimetinib
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
AZD-8330
Compound (Entity type)
0.7162032723426819

cobimetinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PHLDA1
Gene (Entity type)
-0.013013301

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