DHFR (Gene)

Description: dihydrofolate reductase

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View DHFR's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with DHFR.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using DHFR.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for DHFR.

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Gene Sets (1036)

LINCS L1000 Chem Pert Consensus Sigs (357)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (10)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (6)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (654)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (2)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (1)

A gene set library provided by GTEx

IDG Drug Targets 2022 (6)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
DHFR Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	dihydrofolic acid Metabolite (Entity type)
DHFR Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	nadide Metabolite (Entity type)
DHFR Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	sapropterin Metabolite (Entity type)
neutrophil Anatomy (Entity type)	Has marker gene in kidney Knowledge Graph Relation (Entity type)	DHFR Gene (Entity type)
DHFR Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Sapropterin Metabolite (Entity type)
DHFR Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	folic acid Metabolite (Entity type)
DHFR Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	NADP Metabolite (Entity type)
DHFR Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	6R-THF Metabolite (Entity type)
KFGENEBIN:DHFR-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	DHFR Gene (Entity type)
pregnenolone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DHFR Gene (Entity type)	0.0040141703