N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ASPH Gene (Entity type)	0.011717813
N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IKZF1 Gene (Entity type)	-0.008632245
N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AKAP8L Gene (Entity type)	-0.0081434855
N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	EIF5A Gene (Entity type)	0.012124896
N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ISG15 Gene (Entity type)	-0.011414224
N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AQP3 Gene (Entity type)	-0.02114659
N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TMEM100 Gene (Entity type)	-0.008206382
N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TPBG Gene (Entity type)	0.010022771
N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Sphingosine 1-phosphate receptor 2 Protein (Entity type)	IC50
N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CD59 Gene (Entity type)	-0.009796142

N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ASPH
Gene (Entity type)
0.011717813

N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IKZF1
Gene (Entity type)
-0.008632245

N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AKAP8L
Gene (Entity type)
-0.0081434855

N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
EIF5A
Gene (Entity type)
0.012124896

N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ISG15
Gene (Entity type)
-0.011414224

N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AQP3
Gene (Entity type)
-0.02114659

N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TMEM100
Gene (Entity type)
-0.008206382

N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TPBG
Gene (Entity type)
0.010022771

N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Sphingosine 1-phosphate receptor 2
Protein (Entity type)
IC50

N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CD59
Gene (Entity type)
-0.009796142

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