1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Potassium voltage-gated channel subfamily H member 2 Protein (Entity type)	IC50
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SCD5 Gene (Entity type)	-0.0036532423
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	INHBA Gene (Entity type)	0.003595568
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CAV1 Gene (Entity type)	-0.0030684953
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITPRID2 Gene (Entity type)	0.0040339082
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	METRN Gene (Entity type)	0.005098731
ledipasvir Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Compound (Entity type)	0.2998139262199402
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SELENOP Gene (Entity type)	-0.003820073
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MXRA7 Gene (Entity type)	-0.0034744784
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	5-hydroxytryptamine receptor 1A Protein (Entity type)	Ki

1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Potassium voltage-gated channel subfamily H member 2
Protein (Entity type)
IC50

1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SCD5
Gene (Entity type)
-0.0036532423

1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
INHBA
Gene (Entity type)
0.003595568

1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CAV1
Gene (Entity type)
-0.0030684953

1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ITPRID2
Gene (Entity type)
0.0040339082

1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
METRN
Gene (Entity type)
0.005098731

ledipasvir
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
Compound (Entity type)
0.2998139262199402

1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SELENOP
Gene (Entity type)
-0.003820073

1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MXRA7
Gene (Entity type)
-0.0034744784

1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
5-hydroxytryptamine receptor 1A
Protein (Entity type)
Ki

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