(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLAAT4 Gene (Entity type)	-0.008383083
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GBP2 Gene (Entity type)	-0.008743702
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	-0.009223332
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Bromodomain testis-specific protein Protein (Entity type)	IC50
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CASP4 Gene (Entity type)	-0.007477385
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NIBAN1 Gene (Entity type)	-0.011715949
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	C1R Gene (Entity type)	-0.00781698
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CD200 Gene (Entity type)	-0.007879228
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase PLK3 Protein (Entity type)	Kd
2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	0.6113635897636414

(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLAAT4
Gene (Entity type)
-0.008383083

(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GBP2
Gene (Entity type)
-0.008743702

(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
-0.009223332

(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Bromodomain testis-specific protein
Protein (Entity type)
IC50

(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CASP4
Gene (Entity type)
-0.007477385

(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NIBAN1
Gene (Entity type)
-0.011715949

(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
C1R
Gene (Entity type)
-0.00781698

(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CD200
Gene (Entity type)
-0.007879228

(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase PLK3
Protein (Entity type)
Kd

2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
0.6113635897636414

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