N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SCD Gene (Entity type)	0.02516012
N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ITGA6 Gene (Entity type)	-0.0060476037
N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AMOTL2 Gene (Entity type)	-0.0073591038
N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ID1 Gene (Entity type)	-0.006689077
N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TFPI2 Gene (Entity type)	-0.008318059
N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CA2 Gene (Entity type)	-0.0094248485
N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Phospholipase D2 Protein (Entity type)	IC50
clomipramine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide Compound (Entity type)	0.7074404954910278
Fluoxetine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide Compound (Entity type)	0.5289295315742493
1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N(3)-((S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-1H-[1,2,4]triazole-3,5-diamine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide Compound (Entity type)	0.4940305054187774

N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SCD
Gene (Entity type)
0.02516012

N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ITGA6
Gene (Entity type)
-0.0060476037

N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AMOTL2
Gene (Entity type)
-0.0073591038

N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ID1
Gene (Entity type)
-0.006689077

N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TFPI2
Gene (Entity type)
-0.008318059

N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CA2
Gene (Entity type)
-0.0094248485

N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Phospholipase D2
Protein (Entity type)
IC50

clomipramine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
Compound (Entity type)
0.7074404954910278

Fluoxetine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
Compound (Entity type)
0.5289295315742493

1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N(3)-((S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-1H-[1,2,4]triazole-3,5-diamine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
Compound (Entity type)
0.4940305054187774

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