1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LPCAT1 Gene (Entity type)	0.033675462
1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FKBP11 Gene (Entity type)	-0.027982103
1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DHCR24 Gene (Entity type)	0.04926717
1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGCS1 Gene (Entity type)	0.08134806
1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HERPUD1 Gene (Entity type)	-0.039912477
1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FDPS Gene (Entity type)	0.038133547
1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Histone-lysine N-methyltransferase EZH2 Protein (Entity type)	IC50
1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MPPED2 Gene (Entity type)	-0.024567105
1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLBD1 Gene (Entity type)	-0.023552665
1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MSMO1 Gene (Entity type)	0.07150082

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LPCAT1
Gene (Entity type)
0.033675462

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FKBP11
Gene (Entity type)
-0.027982103

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DHCR24
Gene (Entity type)
0.04926717

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGCS1
Gene (Entity type)
0.08134806

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HERPUD1
Gene (Entity type)
-0.039912477

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FDPS
Gene (Entity type)
0.038133547

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Histone-lysine N-methyltransferase EZH2
Protein (Entity type)
IC50

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MPPED2
Gene (Entity type)
-0.024567105

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLBD1
Gene (Entity type)
-0.023552665

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MSMO1
Gene (Entity type)
0.07150082

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