N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PPP1R3C Gene (Entity type)	-0.0059345374
N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 2 Protein (Entity type)	IC50
N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CD40 Gene (Entity type)	0.0073018526
N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PDGFRA Gene (Entity type)	0.0056443345
N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HOXC6 Gene (Entity type)	-0.0051691243
N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RARRES1 Gene (Entity type)	-0.0054442342
N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PNMA2 Gene (Entity type)	-0.0055130553
N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	VU-0424182-2 Compound (Entity type)	0.1702967137098312
N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IKBKE Gene (Entity type)	0.0103732925
N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	0.0058697113

N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PPP1R3C
Gene (Entity type)
-0.0059345374

N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 2
Protein (Entity type)
IC50

N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CD40
Gene (Entity type)
0.0073018526

N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PDGFRA
Gene (Entity type)
0.0056443345

N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HOXC6
Gene (Entity type)
-0.0051691243

N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RARRES1
Gene (Entity type)
-0.0054442342

N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PNMA2
Gene (Entity type)
-0.0055130553

N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
VU-0424182-2
Compound (Entity type)
0.1702967137098312

N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IKBKE
Gene (Entity type)
0.0103732925

N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
0.0058697113

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