(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	E2F2 Gene (Entity type)	0.009866661
(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DHRS7 Gene (Entity type)	0.005699538
(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	H1-2 Gene (Entity type)	-0.006741978
(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCND1 Gene (Entity type)	-0.0062456178
(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CLIC5 Gene (Entity type)	-0.00671178
(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Breakpoint cluster region protein Protein (Entity type)	Kd
(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ACTG2 Gene (Entity type)	0.006035342
(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SPP1 Gene (Entity type)	-0.021649787
(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Cyclobenzaprine Compound (Entity type)	0.3156845271587372
(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NFATC3 Gene (Entity type)	0.006000988

(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
E2F2
Gene (Entity type)
0.009866661

(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DHRS7
Gene (Entity type)
0.005699538

(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
H1-2
Gene (Entity type)
-0.006741978

(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCND1
Gene (Entity type)
-0.0062456178

(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CLIC5
Gene (Entity type)
-0.00671178

(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Breakpoint cluster region protein
Protein (Entity type)
Kd

(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ACTG2
Gene (Entity type)
0.006035342

(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SPP1
Gene (Entity type)
-0.021649787

(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Cyclobenzaprine
Compound (Entity type)
0.3156845271587372

(R)-6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NFATC3
Gene (Entity type)
0.006000988

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Knowledge Graph Assertions

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