N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLA2G2A Gene (Entity type)	0.012818855
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DLK1 Gene (Entity type)	-0.009603214
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SF3A2 Gene (Entity type)	-0.009320043
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	SA-247714 Compound (Entity type)	0.5551571249961853
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FKBP11 Gene (Entity type)	-0.008936503
SA-247714 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	0.5551571249961853
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAGEA3 Gene (Entity type)	-0.017620629
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PNMA2 Gene (Entity type)	0.0123564275
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Histone deacetylase 2 Protein (Entity type)	IC50
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IFI6 Gene (Entity type)	0.013918109

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLA2G2A
Gene (Entity type)
0.012818855

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DLK1
Gene (Entity type)
-0.009603214

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SF3A2
Gene (Entity type)
-0.009320043

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
SA-247714
Compound (Entity type)
0.5551571249961853

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FKBP11
Gene (Entity type)
-0.008936503

SA-247714
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
0.5551571249961853

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MAGEA3
Gene (Entity type)
-0.017620629

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PNMA2
Gene (Entity type)
0.0123564275

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Histone deacetylase 2
Protein (Entity type)
IC50

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IFI6
Gene (Entity type)
0.013918109

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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