N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLA2G2A Gene (Entity type)	0.012818855
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DLK1 Gene (Entity type)	-0.009603214
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SF3A2 Gene (Entity type)	-0.009320043
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	SA-247714 Compound (Entity type)	0.5551571249961853
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FKBP11 Gene (Entity type)	-0.008936503
SA-247714 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	0.5551571249961853
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAGEA3 Gene (Entity type)	-0.017620629
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PNMA2 Gene (Entity type)	0.0123564275
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Histone deacetylase 2 Protein (Entity type)	IC50
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IFI6 Gene (Entity type)	0.013918109

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLA2G2A
Gene (Entity type)
0.012818855

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DLK1
Gene (Entity type)
-0.009603214

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SF3A2
Gene (Entity type)
-0.009320043

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
SA-247714
Compound (Entity type)
0.5551571249961853

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FKBP11
Gene (Entity type)
-0.008936503

SA-247714
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
0.5551571249961853

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MAGEA3
Gene (Entity type)
-0.017620629

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PNMA2
Gene (Entity type)
0.0123564275

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Histone deacetylase 2
Protein (Entity type)
IC50

N-(2-aminophenyl)-4-(((((2R,3S)-9-(dimethylamino)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-2,3,4,5,6,7-hexahydrobenzo[h][1,5]oxazonin-2-yl)methyl)(methyl)amino)methyl)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IFI6
Gene (Entity type)
0.013918109

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