4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	D Protein (Entity type)	Ki
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RBM34 Gene (Entity type)	0.005771028
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Mianserin Compound (Entity type)	0.3059418201446533
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MX1 Gene (Entity type)	0.0055415477
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ANXA3 Gene (Entity type)	0.0046803127
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	-0.0042338595
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Schizophrenia Disease or Phenotype (Entity type)
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IGFBP5 Gene (Entity type)	0.0048164935
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HOPX Gene (Entity type)	-0.0051364442
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PPP3CA Gene (Entity type)	0.005537444

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
D
Protein (Entity type)
Ki

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RBM34
Gene (Entity type)
0.005771028

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Mianserin
Compound (Entity type)
0.3059418201446533

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MX1
Gene (Entity type)
0.0055415477

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ANXA3
Gene (Entity type)
0.0046803127

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
-0.0042338595

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Schizophrenia
Disease or Phenotype (Entity type)

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IGFBP5
Gene (Entity type)
0.0048164935

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HOPX
Gene (Entity type)
-0.0051364442

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PPP3CA
Gene (Entity type)
0.005537444

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