TMEM176A (Gene)

Entrez Gene ID: 55365

Description: transmembrane protein 176A

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TMEM176A's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TMEM176A.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TMEM176A.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TMEM176A.

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Gene Sets (2790)

LINCS L1000 Chem Pert Consensus Sigs (804)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (2)

A gene set library provided by GlyGen

LINCS L1000 CRISPR KO Consensus Sigs (666)

A gene set library provided by LINCS

rummageo gene perturbations (68)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (1164)

A gene set library provided by LINCS

rummageo chemical perturbations (80)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (4)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (1)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Iguratimod Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	0.0055330005
SID11111654 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	-0.00543563
(2R,3S)-3-(isopropylamino)-1-(7-methyl-2,3-dihydro-1H-inden-4-yloxy)butan-2-ol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	0.010191515
SA-1460136 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	0.012843952
Zidovudine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	0.004771528
4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	-0.0042338595
3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-1-morpholin-4-yl-propan-1-one (WEB 2086) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	-0.004404886
SA-89735 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	0.013634124
N4-(3-Bromo-phenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	0.010737173
palomid-529 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TMEM176A Gene (Entity type)	0.003126429

Iguratimod
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
0.0055330005

SID11111654
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
-0.00543563

(2R,3S)-3-(isopropylamino)-1-(7-methyl-2,3-dihydro-1H-inden-4-yloxy)butan-2-ol
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
0.010191515

SA-1460136
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
0.012843952

Zidovudine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
0.004771528

4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
-0.0042338595

3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-1-morpholin-4-yl-propan-1-one (WEB 2086)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
-0.004404886

SA-89735
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
0.013634124

N*4*-(3-Bromo-phenyl)-N*6*-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
0.010737173

palomid-529
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TMEM176A
Gene (Entity type)
0.003126429

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Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.