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Tolcapone (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Tolcapone's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Tools & Use Cases

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	Tolcapone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DNAJA3 Gene (Entity type)	0.0053953533
	testosterone-enanthate Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Tolcapone Compound (Entity type)	0.1477406322956085
	Tolcapone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PDGFRA Gene (Entity type)	0.0059953905
	Oxybutynin Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Tolcapone Compound (Entity type)	0.3543567955493927
	1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Tolcapone Compound (Entity type)	0.3047218024730682
	Tolcapone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SCGB2A2 Gene (Entity type)	0.0051321774
	Tolcapone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AKR1C3 Gene (Entity type)	-0.0061979056
	Tolcapone Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Parkinson Disease Disease or Phenotype (Entity type)
	Tolcapone Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Catechol O-methyltransferase Protein (Entity type)	Ki
	Tolcapone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GNAS Gene (Entity type)	0.004888711

Tolcapone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DNAJA3
Gene (Entity type)
0.0053953533

testosterone-enanthate
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Tolcapone
Compound (Entity type)
0.1477406322956085

Tolcapone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PDGFRA
Gene (Entity type)
0.0059953905

Oxybutynin
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Tolcapone
Compound (Entity type)
0.3543567955493927

1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Tolcapone
Compound (Entity type)
0.3047218024730682

Tolcapone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SCGB2A2
Gene (Entity type)
0.0051321774

Tolcapone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AKR1C3
Gene (Entity type)
-0.0061979056

Tolcapone
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Parkinson Disease
Disease or Phenotype (Entity type)

Tolcapone
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Catechol O-methyltransferase
Protein (Entity type)
Ki

Tolcapone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GNAS
Gene (Entity type)
0.004888711

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