2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-4 Protein (Entity type)	IC50
2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	IC50
2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Activin receptor type-2B Protein (Entity type)	IC50
2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase B-raf Protein (Entity type)	IC50
2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	TGF-beta receptor type-1 Protein (Entity type)	IC50
2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lyn Protein (Entity type)	IC50
2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Nuclear receptor coactivator 1 Protein (Entity type)	IC50
2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase BTK Protein (Entity type)	IC50

2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-4
Protein (Entity type)
IC50

2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
IC50

2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Activin receptor type-2B
Protein (Entity type)
IC50

2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase B-raf
Protein (Entity type)
IC50

2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
TGF-beta receptor type-1
Protein (Entity type)
IC50

2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lyn
Protein (Entity type)
IC50

2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Nuclear receptor coactivator 1
Protein (Entity type)
IC50

2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase BTK
Protein (Entity type)
IC50

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