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Tyrosine-protein kinase Lck (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Tyrosine-protein kinase Lck 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methyl-N-m-tolylbenzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	IC50
	N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(4-ethylpiperazin-1-yl)-5-(trifluoromethyl)benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	IC50
	N-[4-(2-Chloro-6-methyl-phenylamino)-imidazo[1,5-a]quinoxalin-8-yl]-acetamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	IC50
	2-[2-(2-Hydroxy-2-methyl-propylamino)-6-methyl-pyrimidin-4-ylamino]-benzothiazole-6-carboxylic acid (2-chloro-6-methyl-phenyl)-amide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	IC50
	(S)-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	IC50
	4-(4-(5-hydroxy-2-methylphenylamino)quinolin-7-yl)thiazole-2-carbaldehyde Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	Ki
	OSI-930 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	IC50
	(2-Chloro-6-methyl-phenyl)-(7,9-dioxa-2,5,10b-triaza-dicyclopenta[a,g]naphthalen-4-yl)-amine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	IC50
	compound 23 [PMID: 17600705] Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	IC50
	compound 2 [PMID: 15546730] Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Lck Protein (Entity type)	IC50

3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methyl-N-m-tolylbenzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
IC50

N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(4-ethylpiperazin-1-yl)-5-(trifluoromethyl)benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
IC50

N-[4-(2-Chloro-6-methyl-phenylamino)-imidazo[1,5-a]quinoxalin-8-yl]-acetamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
IC50

2-[2-(2-Hydroxy-2-methyl-propylamino)-6-methyl-pyrimidin-4-ylamino]-benzothiazole-6-carboxylic acid (2-chloro-6-methyl-phenyl)-amide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
IC50

(S)-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
IC50

4-(4-(5-hydroxy-2-methylphenylamino)quinolin-7-yl)thiazole-2-carbaldehyde
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
Ki

OSI-930
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
IC50

(2-Chloro-6-methyl-phenyl)-(7,9-dioxa-2,5,10b-triaza-dicyclopenta[a,g]naphthalen-4-yl)-amine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
IC50

compound 23 [PMID: 17600705]
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
IC50

compound 2 [PMID: 15546730]
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Lck
Protein (Entity type)
IC50

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