N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IFI27 Gene (Entity type)	-0.0032052496
N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SNAP25 Gene (Entity type)	0.005172547
N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	72 kDa type IV collagenase Protein (Entity type)	IC50
N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GOLGA8A Gene (Entity type)	0.0030591558
N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NME4 Gene (Entity type)	0.0035858424
N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Matrilysin Protein (Entity type)	IC50
N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ABCA8 Gene (Entity type)	-0.0039226515
N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SLC30A1 Gene (Entity type)	-0.003222479
N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	azelaic-acid Compound (Entity type)	0.2826057076454162
N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	S100P Gene (Entity type)	0.0030082117

N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IFI27
Gene (Entity type)
-0.0032052496

N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SNAP25
Gene (Entity type)
0.005172547

N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
72 kDa type IV collagenase
Protein (Entity type)
IC50

N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GOLGA8A
Gene (Entity type)
0.0030591558

N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NME4
Gene (Entity type)
0.0035858424

N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Matrilysin
Protein (Entity type)
IC50

N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ABCA8
Gene (Entity type)
-0.0039226515

N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SLC30A1
Gene (Entity type)
-0.003222479

N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
azelaic-acid
Compound (Entity type)
0.2826057076454162

N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
S100P
Gene (Entity type)
0.0030082117

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1*-dihydroxy-3-isobutyl-succinamide (Compound)

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Knowledge Graph Assertions

Knowledge Graph Assertions

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Knowledge Graph Assertions

N4-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N1-dihydroxy-3-isobutyl-succinamide (Compound)