3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MARCKS Gene (Entity type)	0.00398207
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cytochrome P450 2C9 Protein (Entity type)	IC50
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cytochrome P450 2D6 Protein (Entity type)	IC50
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FASTKD5 Gene (Entity type)	-0.004783127
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LUM Gene (Entity type)	0.003952675
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	0.0037087193
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Polyunsaturated fatty acid 5-lipoxygenase Protein (Entity type)	IC50
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TFPI2 Gene (Entity type)	-0.0044728382
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMOX1 Gene (Entity type)	0.004008308
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TMEM158 Gene (Entity type)	-0.0034770654

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MARCKS
Gene (Entity type)
0.00398207

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cytochrome P450 2C9
Protein (Entity type)
IC50

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cytochrome P450 2D6
Protein (Entity type)
IC50

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FASTKD5
Gene (Entity type)
-0.004783127

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LUM
Gene (Entity type)
0.003952675

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PHGDH
Gene (Entity type)
0.0037087193

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Polyunsaturated fatty acid 5-lipoxygenase
Protein (Entity type)
IC50

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TFPI2
Gene (Entity type)
-0.0044728382

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMOX1
Gene (Entity type)
0.004008308

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TMEM158
Gene (Entity type)
-0.0034770654

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