N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FASTKD5 Gene (Entity type)	0.0038383347
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MMP9 Gene (Entity type)	0.0047565456
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	BASP1 Gene (Entity type)	-0.00452243
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RPS27L Gene (Entity type)	-0.003836159
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Angiopoietin-1 receptor Protein (Entity type)	IC50
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	IC50
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PDE4DIP Gene (Entity type)	-0.0034912864
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CD59 Gene (Entity type)	0.0040849806
SID11113496 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	0.2506337761878967
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KRCC1 Gene (Entity type)	-0.0036344172

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FASTKD5
Gene (Entity type)
0.0038383347

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MMP9
Gene (Entity type)
0.0047565456

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
BASP1
Gene (Entity type)
-0.00452243

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RPS27L
Gene (Entity type)
-0.003836159

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Angiopoietin-1 receptor
Protein (Entity type)
IC50

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
IC50

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PDE4DIP
Gene (Entity type)
-0.0034912864

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CD59
Gene (Entity type)
0.0040849806

SID11113496
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
0.2506337761878967

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
KRCC1
Gene (Entity type)
-0.0036344172

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