LYN (Gene)

Entrez Gene ID: 4067

Description: LYN proto-oncogene, Src family tyrosine kinase

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LYN's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with LYN.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using LYN.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for LYN.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with LYN.

Gene Sets (3575)

LINCS L1000 Chem Pert Consensus Sigs (750)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (17)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (17)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (906)

A gene set library provided by LINCS

rummageo gene perturbations (221)

A gene set library provided by LINCS

RummaGEO DrugPerturbations 2025 (442)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (920)

A gene set library provided by LINCS

rummageo chemical perturbations (277)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (1)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (2)

A gene set library provided by GTEx

IDG Drug Targets 2022 (22)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
cebranopadol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	-0.020525107
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	0.0064036264
repaglinide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	-0.0037310957
Methenamine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	-0.013838575
Oxiconazole Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	0.0046276273
SA-1920013 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	-0.00903746
SID11114136 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	0.0043239277
efaproxiral Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	-0.0038064169
Acrivastine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	-0.0054827896
2-iminobiotin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	-0.0054181335

cebranopadol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
-0.020525107

isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
0.0064036264

repaglinide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
-0.0037310957

Methenamine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
-0.013838575

Oxiconazole
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
0.0046276273

SA-1920013
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
-0.00903746

SID11114136
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
0.0043239277

efaproxiral
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
-0.0038064169

Acrivastine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
-0.0054827896

2-iminobiotin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
-0.0054181335

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.