TBL1XR1 (Gene)

Organism:

Homo sapiens

Synonyms:C21, DC42, ENTREZ:79718, HGNC:29529, IRA1, MIM:608628, MRD41, NM_001321193, NM_001321194, NM_001321195, NM_001374327, NM_001374328, NM_001374329, NM_001374330, NM_024665, NP_001308122, NP_001308123, NP_001308124, NP_001361256, NP_001361257, NP_001361258, NP_001361259, NP_078941, TBL1X receptor 1, TBL1XR1, TBLR1, XM_006713746, XM_011513141, XM_011513142, XM_011513143, XM_024453751, XM_024453752, XP_006713809, XP_011511443, XP_011511444, XP_011511445, XP_024309519, XP_024309520

Omim:OMIM:608628

Id:ENSG00000177565

Hgnc:HGNC:29529

Entrez:79718

Ensembl:ENSG00000177565

Description:TBL1X/Y related 1

This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TBL1XR1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with TBL1XR1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TBL1XR1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TBL1XR1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TBL1XR1.

Results found

Linked to

	Label	Description
	GSE120612 etoposide leukocyte 7 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE153871 cytarabine U2OS 4 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE57871 GLI1 PSMD13 knockdown HCT 116 Vorinostat 11 v 12 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE190937 AHCY MAT2A knockout Rael 4 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE57871 vorinostat HCT 116 11 v 12 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE120612 7 V 2 ETOPOSIDE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE158632 quinoline HT-29 Caco-2 2 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE235701 GSE261434 enasidenib 2 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE119424 GSE120214 TBXT brachyury inhibition 7 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE120612 etoposide leukocyte 7 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE153871 cytarabine U2OS 4 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE57871 GLI1 PSMD13 knockdown HCT 116 Vorinostat 11 v 12 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE190937 AHCY MAT2A knockout Rael 4 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE57871 vorinostat HCT 116 11 v 12 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE120612 7 V 2 ETOPOSIDE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE158632 quinoline HT-29 Caco-2 2 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE235701 GSE261434 enasidenib 2 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE119424 GSE120214 TBXT brachyury inhibition 7 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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