PFKL (Gene)

Ensembl Gene ID: ENSG00000141959

Entrez Gene ID: 5211

Description: phosphofructokinase, liver type

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PFKL's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PFKL.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PFKL.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PFKL.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PFKL.

Gene Sets (3208)

LINCS L1000 Chem Pert Consensus Sigs (870)

A gene set library provided by LINCS

Metabolomics Workbench Metabolites 2022 (10)

A gene set library provided by MW

ARCHS4 IDG Coexp (12)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (2)

A gene set library provided by GlyGen

LINCS L1000 CRISPR KO Consensus Sigs (528)

A gene set library provided by LINCS

rummageo gene perturbations (126)

A gene set library provided by LINCS

RummaGEO DrugPerturbations 2025 (362)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (1079)

A gene set library provided by LINCS

rummageo chemical perturbations (216)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (3)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Lomustine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PFKL Gene (Entity type)	0.005773376
erythromycin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PFKL Gene (Entity type)	0.004401679
N-(3-(N-(3-(3,5-dimethoxyphenylamino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylbenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PFKL Gene (Entity type)	0.0035028101
US9138393, Climbazole::US9144538, Climbazole Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PFKL Gene (Entity type)	-0.005346866
norethindrone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PFKL Gene (Entity type)	0.0060148677
PF-4800567 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PFKL Gene (Entity type)	0.005344541
cyclosporin-a Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PFKL Gene (Entity type)	-0.0045777755
PFKL Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Uridine Triphosphate Metabolite (Entity type)
VU-0404997-2 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PFKL Gene (Entity type)	0.014127847
(Z)-6-[(2S,4S,5R)-2-(2-Chloro-phenyl)-4-(2-hydroxy-phenyl)-[1,3]dioxan-5-yl]-hex-4-enoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PFKL Gene (Entity type)	-0.0048217946

Lomustine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PFKL
Gene (Entity type)
0.005773376

erythromycin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PFKL
Gene (Entity type)
0.004401679

N-(3-(N-(3-(3,5-dimethoxyphenylamino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylbenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PFKL
Gene (Entity type)
0.0035028101

US9138393, Climbazole::US9144538, Climbazole
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PFKL
Gene (Entity type)
-0.005346866

norethindrone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PFKL
Gene (Entity type)
0.0060148677

PF-4800567
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PFKL
Gene (Entity type)
0.005344541

cyclosporin-a
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PFKL
Gene (Entity type)
-0.0045777755

PFKL
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
Uridine Triphosphate
Metabolite (Entity type)

VU-0404997-2
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PFKL
Gene (Entity type)
0.014127847

(Z)-6-[(2S,4S,5R)-2-(2-Chloro-phenyl)-4-(2-hydroxy-phenyl)-[1,3]dioxan-5-yl]-hex-4-enoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PFKL
Gene (Entity type)
-0.0048217946

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.