ITK (Gene)

Description: IL2 inducible T cell kinase

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ITK's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ITK.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ITK.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ITK.

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Gene Sets (892)

LINCS L1000 Chem Pert Consensus Sigs (386)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (8)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (3)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (468)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (7)

A gene set library provided by GTEx

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (9)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (2)

A gene set library provided by GTEx

IDG Drug Targets 2022 (9)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Kidney_L3_T cell Anatomy (Entity type)	Has marker gene in kidney Knowledge Graph Relation (Entity type)	ITK Gene (Entity type)
sulfamonomethoxine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ITK Gene (Entity type)	-0.015520761
SR-33805 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ITK Gene (Entity type)	-0.005372707
SA-102607 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ITK Gene (Entity type)	-0.01360751
SD-6-035-B3 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITK Gene (Entity type)	0.006793954
DAC-004 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITK Gene (Entity type)	0.014093302
T-Lymphocyte Anatomy (Entity type)	Has marker gene in heart Knowledge Graph Relation (Entity type)	ITK Gene (Entity type)
Lamivudine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ITK Gene (Entity type)	-0.003903254
Homosalate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITK Gene (Entity type)	0.0073552583
Varlitinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ITK Gene (Entity type)	-0.0039216806