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Receptor-type tyrosine-protein kinase FLT3 (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Receptor-type tyrosine-protein kinase FLT3 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	4-((2-isopropylthieno[2,3-d]pyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	IC50
	(Z)-N1-(3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N3-(4-methoxyphenyl)malonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	IC50
	N-(3-Fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	IC50
	N1-[3-(4-[(Anilinocarbonyl)amino]methylphenyl)-1H-5-pyrazolyl]-4-[(4-methylpiperazino)methyl]benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	IC50
	4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-(4-(piperazin-1-ylmethyl)phenyl)-1H-pyrazole-3-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	IC50
	(+)-3-((tert-butylamino)(pyridin-2-yl)methyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	IC50
	1-(4-(3-aminobenzo[d]isoxazol-4-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	IC50
	2-(6,7-dimethoxyquinazolin-4-ylthio)thiazole Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	IC50
	N-(5-Methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	IC50
	SID103904281 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-type tyrosine-protein kinase FLT3 Protein (Entity type)	Ki

4-((2-isopropylthieno[2,3-d]pyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
IC50

(Z)-N1-(3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N3-(4-methoxyphenyl)malonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
IC50

N-(3-Fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
IC50

N1-[3-(4-[(Anilinocarbonyl)amino]methylphenyl)-1H-5-pyrazolyl]-4-[(4-methylpiperazino)methyl]benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
IC50

4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-(4-(piperazin-1-ylmethyl)phenyl)-1H-pyrazole-3-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
IC50

(+)-3-((tert-butylamino)(pyridin-2-yl)methyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
IC50

1-(4-(3-aminobenzo[d]isoxazol-4-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
IC50

2-(6,7-dimethoxyquinazolin-4-ylthio)thiazole
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
IC50

N-(5-Methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
IC50

SID103904281
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-type tyrosine-protein kinase FLT3
Protein (Entity type)
Ki

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