8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)'s neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITGB1BP1 Gene (Entity type)	0.0032967278
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	METRN Gene (Entity type)	-0.0039984765
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ABAT Gene (Entity type)	-0.003209942
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CSRP2 Gene (Entity type)	0.0035767292
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FEZ1 Gene (Entity type)	-0.003265054
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	COG7 Gene (Entity type)	-0.0034960788
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DES Gene (Entity type)	0.002855244
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SIRT3 Gene (Entity type)	-0.002882163
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MYLK Gene (Entity type)	0.0030001553
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone) Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Tipiracil Compound (Entity type)	0.2544487714767456

8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ITGB1BP1
Gene (Entity type)
0.0032967278

8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
METRN
Gene (Entity type)
-0.0039984765

8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ABAT
Gene (Entity type)
-0.003209942

8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CSRP2
Gene (Entity type)
0.0035767292

8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FEZ1
Gene (Entity type)
-0.003265054

8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
COG7
Gene (Entity type)
-0.0034960788

8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DES
Gene (Entity type)
0.002855244

8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SIRT3
Gene (Entity type)
-0.002882163

8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MYLK
Gene (Entity type)
0.0030001553

8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione (Buspirone)
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Tipiracil
Compound (Entity type)
0.2544487714767456

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